N-LONE-D300 (Nandrolone decanoate, Nandrolone, Deca) is an anabolic steroid which is naturally found in the human body although in small quantities. It is most commonly sold with the name Deca-Durabolin as its decanoate ester and less commonly as a Durabolin. Nandrolone decanoate is an effective drug to cure osteoporosis in women during the postmenopausal process at a dose of 50 mg every three weeks (though not recommended).
It has some important use for some aplastic anemias. This drug has positive effects including muscle growth, appetite stimulation and increased red blood cell production and bone density. Clinical studies have reached to the conclusion that this drug is an effective treatment for anemia, osteoporosis and some forms of neoplasia like breast cancer. It also acts as a progestin-based contraceptive. As Nandrolone is not much broken down into DHT, the toxic effects of this drug of most anabolic steroids on the scalp, skin and prostate become minimized to a degree. The lack of alkylation on the 17α-carbon significantly makes the drug less toxic for the liver. Estrogenic effects due to the reaction with aromatize are also mitigated as a result of the drug being a progestin. However, side effects like gynaecomastia and reduced libido still occur if doses are taken in larger quantities.
Nandrolone decanoate in bodybuilding
It is more effective at the androgen receptor of muscle tissues as compared to the testosterone: it binds better. However it gives simply about half the muscle building resulting which is the result of its being less effective or entirely not effective in non-AR-mediated mechanisms for muscle gains. It seems less or wholly ineffective in the activity on nerve cells and it’s responsible for erectile function on the nerve cells. The sole use of Nandrolone often leads to complete inability to perform sexually and this problem can be solved by combining it with such drug that does supply the missing activity. It is usually combined with testosterone (Sustanon, Testosterone enanthate). Nandrolone decanoate is a very effective anabolic drug which gives quality muscle gains. Such effectiveness of this drug probably, is due to its moderately strong binding effect to the Androgen receptors, or its several positive non Androgen-Receptor mediated Special effects. One of such effects is nitrogen retention that is a major factor in muscle growth and mass gains.
In one research, with the low doses of Nandrolone (65 mg/week) and high-doses of Nandrolone (200 mg/week), both resulted in visible nitrogen retention (33-52 g nitrogen/14 days, showing gains of 0.5 to 0.9 kg lean tissue/week), and body weight enhanced by 4.9 +/- 1.2 kg, including 3.1 +/- 0.5 kg lean body mass, and treadmill exercise performance (cardiovascular fitness) also improved.
Nandrolone decanoate side effects
There are many complaints of water retention regarding this drug in several cases. Letrozole (Femara) seems to be a great choice to solve this problem and it makes Nandrolone quite suitable for bulking rather than cutting, it can be productively used for either. Nandrolone is a progestin, unluckily; it stimulates progesterone receptor 20% as well as progesterone itself. Such situation brings many unwanted side effects like water retention, acne, etc. There is an important point to be noted that most of those are rare, though. It may be the major reason when Nandrolone comes to your natural testosterone level, it proves an intensive drug. Hence Nandrolone should not be used alone, but should be taken with testosterone. 200 mgs is a minimum dose which has been suggested to avoid impotence and sexual dysfunction. In order to minimize the increased anabolic effect, anti-progesterone drugs with Nandrolone are suggested and Cabergoline (Dostinex) and Bromocription (Gynode) are good choices in this regard. The moderately effective dose of this drug is suggested as 400mgs per week. Nandrolone is not suitable to short alternating cycles due to its long half-life. But it is suitable for more traditional cycles, with a built-in self-tapering effect in the weeks following the last injection.